Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects
نویسندگان
چکیده
منابع مشابه
Speaker 1: Francesc Artigas, Spain
Major depression is a severe and heterogeneous psychiatric disease with high, increasing prevalence and socio-economic impact.1 The serotonergic system is implicated in the etiology and treatment of mood disorders.2 Most prescribed antidepressants, the selective serotonin (5-HT) reuptake inhibitors (SSRI) and the dual 5-HT and norepinephrine reuptake inhibitors block physiological reuptake mech...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2011
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2011.92